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Cannabis Cannabis use disorder (CUD) remains the least studied SUD in this context, but early data have been promisingone retrospective chart review of nearly 100,000 patients with obesity found that a semaglutide prescription decreased the incidence of CUD by approximately 50% (Wang W et al, Molecular Psychiatry 2024;29:25872598)

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This ultimately leads to hepatocyte necrosis, triggering the release of DAMPs