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Tirzepatide (Zepbound) achieved an average of 22.5% at the highest dose over 72 weeks in SURMOUNT-1 (2,539 adults)

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Similar beneficial effects have been achieved using genetic models, such as GIPR / and GIP / mice, and immunoneutralization of GIP or the GIPR using specific mAbs (110, 180, 185, 187-189)

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