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4) were His41, Met49, Cys145, His163, Met165, Pro168, Arg188, Thr190, and Gln192, the nucleophilic atom reacting was in favor of the ketone function side of Arg188 and the hydroxyl function of the tocopherols represented by the hydrogen as the electrophilic atom, only one hydrogen bond was recorded in this context and that clarifies the native structure of the Arg since the other side of it ends with a guanidinium group which enables the formation of hydrogen bonds due to the delocalization of the positive charge of the nitrogen atom in the Arg bone structure

doi: 10.3389/fphar.2022.949260

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