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During this process, osteoclasts attach to the old bone and dissolve minerals and digest bone matrix by releasing proteases and acidic products

Oxidative stress is a major cause of stem cell senescence and dysfunction

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Exosomes have many potential as drug carriers, such as through penetration through a wide range of biological barriers, natural targeting capabilities, biocompatibility, less immunogenicity than synthetic NPs, stability, and the ability to deliver both large and small biological molecules [147, 148]