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Author contributions AR: Conceptualization, Writing original draft, Formal analysis, Investigation, Methodology, Writing review & editing

Gonadal steroids can also influence GLP-1R expression in the brain and other tissuesin the whole hypothalamus, for example, the highest GLP-1R expression is found in the late proestrus stage (46), providing further mechanistic support for potentially higher sensitivity to GLP-1 effects during this phase of the cycle (33, 47)

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Metformin is often considered for women with PCOS who have metabolic features or impaired glucose regulation, particularly as it has a well-established safety profile, oral administration, and cost-effectiveness