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Agitation scaling was performed to match power input per diameter of the impeller cubed, reflective of the shear sensitivity of microcarrier-bound cells and higher shear in the area immediately surrounding the impeller

These results have been successfully replicated in studies using other animal models

Repeatedly injecting in the same location can lead to lipohypertrophy, a condition characterized by lumpy, thickened areas of fatty tissue that can impair medication absorption and lead to unpredictable blood glucose levels