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It tends to occur most frequently during the first few weeks of treatment or immediately after dose increases, as the gut adjusts to the new GLP-1 signaling levels
Some clinicians suggest intermittent or reduced-dose GLP-1 therapy as a maintenance strategy, though this approach remains investigational and lacks robust evidence
for example, GIP plus glucagon or a triagonist comprising GIP, GLP-1 and glucagon is also being developed for patients with obesity, diabetes or dyslipidaemia
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