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However, this trial was limited by small sample size and potential flaws in the selection of endpoints (NCT04916470 and NCT05371496) [52]
At the same time, it exhibits a favorable safety profile in animal studies
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Recent advancements in structural biology and electrophysiology have shed light on the molecular architecture governing MIC activation, demonstrating that force-induced conformational changes within channel domains, along with their dynamic interactions with cytoskeletal components, dictate the gating behavior in response to mechanical stress
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