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Future studies that include cause-of-death data would be instrumental in clarifying this relationship

Produced by osteoblasts and released into circulationparticularly in its undercarboxylated formosteocalcin has been shown in animal models to enhance insulin secretion, improve insulin sensitivity, increase energy expenditure, and stimulate testosterone production ( Mechanistically, osteocalcin signaling has been linked to the G proteincoupled receptor GPRC6A, providing a plausible pathway through which bone-derived signals influence pancreatic -cells, adipocytes, and Leydig cells

Vitamin C and E As Antioxidants Both vitamin C and E are antioxidants that support normal bodily functions, including supporting the production of glutathione

Aging Cell 21 , e13676 (2022)