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The first experience available in the literature on an oral food supplement containing quercetin, and not contained within a plant ingredient of the compound, dates back to 2015, when Ariano conducted an open-label study with an oral supplement containing dry extract of Perilla frutescens 80 mg (containing several flavonoids), quercetin 150 mg, and vitamin D3 5 mcg (200 IU)

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Biomedicine & Pharmacotherapy, 2003

The Q141K mutation is also linked with this phenotype of renal uric acid overload, both in patients who are homozygous for Q141K and those who are heterozygous for Q126X and Q141K