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Unsuppressed water acquisitions were acquired from each voxel to provide a reference for absolute quantification and corrected for voxel CSF, which was greater in established patients but unaffected by diagnosis (Supplementary Figure 3.1 and Table 3.1)

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Difficulty achieving dissolution during reconstitution If epitalon does not dissolve completely with standard bacteriostatic water reconstitution, adding a small amount of 0.6 percent acetic acid before the bacteriostatic water may aid dissolution