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Maintaining adequate hydration is essential, particularly with topiramate Metabolic monitoring : Regular assessment of kidney function, electrolytes, and acid-base balance is advisable Weight loss monitoring : Whilst often desired, excessive or rapid weight loss should be evaluated Cognitive function : Topamax's cognitive effects may be more problematic if compounded by any metabolic disturbances If you experience severe or persistent side effects, contact your healthcare provider promptly

Tirzepatide GLP-1 agonists like Semaglutide help to control your blood sugar, but people taking them also tend to lose weight

These pleiotropic actions, combined with robust analgesic and antifibrotic effects, support GLP-1 analogues as a promising new therapeutic class for OA

Science Progress 2026