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Hospitalization: Repeated ER visits for cyclic vomiting or severe dehydration lasting four weeks or longer

As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]

Available at: Hong W et al

Experience gentle daily care with Brilliant Skin Essentials Gluta-Arbutin Soap, a maintenance bar specially formulated to help keep skin feeling smooth, hydrated, and renewed