Moreover, a 2021 meta-analysis of five studies that included 868 patients reported that GM1 did not reduce the incidence of grade 2 or higher CIPN or other adverse effects of chemotherapybut also did not reduce therapeutic effects of treatment (Wu 2021)
Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
Additionally, its progression is influenced by inflammation, the renin-angiotensin system (RAAS), advanced glycation end-product (AGE) formation, and signaling molecules, including transforming growth factor-1 (TGF-1), connective tissue growth factor (CTGF), PKC, MAPK, and ROS
Oftentimes whether its for health optimization or disease treatment, we have other FDA-approved options. Dr