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Zepbound and Ozempic share most of the same potential side effects, including: Gastrointestinal issues (nausea, diarrhea, constipation, vomiting, abdominal pain) Injection site reactions (redness, itching, bumps, or swelling) Serious adverse effects include hypoglycemia (especially when used along with insulin or certain diabetes medicines), pancreatitis, gallbladder problems, kidney injury, and worsening diabetic retinopathy