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ScGrx7 is particularly suited for unbiased kinetic and mechanistic studies because of its high activity, the absence of ironsulfur clusters in enzyme preparations and the lack of additional cysteine residues 11 (glutaredoxins with two or more cysteine residues have complex kinetics because of alternative redox states and reactions 10,12,14,17,30,31,32,33 )

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The angiogenic effect is not direct on isolated cells in culture but appears in vivo when blood vessels and surrounding tissue are present (Brcic et al., 2009)

Additional file 5 (download XLSX Included and excluded studies