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Demonstrated clinical benefits of GLP-1s include improved cardiometabolic risks, fewer major adverse cardiovascular events [22], decreased mortality in heart failure [[23], [24], [25], [26], [27]], and improvements in obstructive sleep apnea [11,28], prediabetes [29,30], chronic kidney disease [31], knee osteoarthritis [32], substance use disorders [33], and metabolic-associated steatotic liver disease [34]

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