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Another mechanism of epigenetic regulation is mediated by microRNAs, which cause the degradation of genes involved in the development and progression of BBB dysfunction (Figure 2) (Ma et al., 2020)

FDA lacks important information regarding any safety issues raised by KPV, including whether it would cause harm if administered to humans.18 In other words, there have been no dedicated safety studies on KPV, so its status as a safe or unsafe therapy is up in the air