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GPER also regulates adipocyte function, affecting fatty acid synthesis and oxidation to modulate fat metabolism [4]

The increase in appetite might be related to the agonistic effect of Ipamorelin on ghrelin receptors which may stimulate hunger, as well as the increase in insulin production observed in animal experiments

Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)

20 Kuhnen P, Wabitsch M, von Schnurbein J, et al