Although almost all tissues in the body have some ability to metabolize chemicals, smooth endoplasmic reticulum in the liver is the principal "metabolic clearing house" for both endogenous chemicals (e.g., cholesterol, steroid hormones, fatty acids, proteins) and exogenous substances (e.g., drugs, alcohol)
BMJ 388:e080679
On the other hand, while the triagonist, GLP1/GIP/Glucagon, was very effective in terms of body weight lowering, in keeping with previous references 42 , treatment of PWA mice led to a massive, likely detrimental weight loss, also at the expense of lean mass, that was not bound to clear amelioration of glucose intolerance in androgenized female mice
It could potentially help or cause a flare-up, so any research in this context must be done with extreme care and monitoring