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Key specifications: Quantity: 50mg per vial Form: Lyophilised powder (unless stated otherwise) Appearance: White/offwhite (typical) Storage: Store cold, dry, protected from light/moisture (confirm per label/COA) Documentation: COA / SDS / lot number (where available) Intended use: Nonclinical laboratory research only

Insulin doses were log-transformed before analysis to account for their skewed distribution and estimated ratio to baseline were transformed back for interpretation expressed as percent change from baseline to week 40 and estimated percent difference vs placebo

Humulin N is an intermediate-acting insulin