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4.41 months), and the quality of life (QoL) was improved, establishing it as the cornerstone of first-line treatment for pancreatic ductal adenocarcinoma (PDAC) ( Between the 2000s and 2010s, as gemcitabine showed good antitumor activity and tolerability, it began to be extended to other solid tumors: In 2002, the FDA approved the combination of gemcitabine and cisplatin for non-small cell lung cancer (NSCLC), and compared with cisplatin alone, the OS was significantly prolonged, becoming one of the first-line standard regimens for NSCLC ( Since the 2010s, with the increasing recognition of gemcitabine resistance, researchers have explored various combination therapies

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10.1016/j.cbpc.2018.02.006 21 FrostT