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The selectivity profile confirmed in multiple rodent and early human studies allows researchers to attribute observed experimental outcomes specifically to GH-axis modulation rather than to concurrent adrenal or lactotroph activation, a significant methodological advantage over the hexapeptide GHRPs
Additionally, another study demonstrated that dsDNA-triggered cGAS-STING signaling augmented the migratory and invasive capabilities of RA-FLSs, which were suppressed by cGAS or STING short hairpin RNA treatment (64)
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