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Patients interested in the broader comparison between semaglutide with B12 and tirzepatide with B12 should consider that both benefit from the added vitamin, but the underlying mechanism of tirzepatide (dual receptor activation) provides a different therapeutic profile

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Other serious adverse events can include severe nausea and vomiting leading to dehydration, acute kidney injury, particularly in patients with existing kidney disease, and diabetic retinopathy complications in some patients with diabetes