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Consequently, the development of kidney-specific antisense oligonucleotide (ASO) or adeno-associated viral (AAV) transduction methods is advantageous, as these approaches can selectively inhibit ANGPTL4 in proximal tubules, glomerular podocytes, and glomerular endothelial cells, thereby avoiding the adverse systemic effects associated with whole-body ANGPTL4 loss (Srivastava et al., 2024)

This approach, standard in clinical protocols, reduces the intensity of both gastrointestinal side effects and potential allergic responses

As of June 2026, no generic semaglutide is FDA-approved in the United States

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