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If your dietary sources are insufficient, you may consider supplements, such as pills or injections, depending on the cause of the deficiency

Take it at the same time daily, preferably on an empty stomach

The interaction is so dangerous that the FDA has included a boxed warning, the most serious type of alert, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Other Drug Classes That Cause Drowsiness Any CNS depressant, listed in the above table, can be problematic when used with alprazolam, because they increase the risk of drowsiness, dizziness, being off-balance, and difficulty concentrating