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The risk of ION (ICD-10-CM:H47.01) and legal blindness as defined by the USA (ICD-10-CM:H54.8) were the primary outcomes measured in this study

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Subsequently, secondary bile acids, key signaling molecules produced by bile acids and gut microbiota metabolism, are bound to membrane receptors (Takeda G protein-coupled receptor 5, TGR5/G protein-coupled bile acid receptor 1, GPBAR1) and nuclear receptors (Farnesoid X Receptor, FXR), which stimulates colonic secretion of GLP-1 and PYY

A study of 132 cirrhotics demonstrated CHE to be heterogeneous syndrome requiring a combination of clinical and neuropsychometric indicators for diagnosis [12]