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The GRAS designation has created regulatory ambiguity: while AOD-9604 supplements are legally available, their marketing often implies therapeutic benefits that remain unproven

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(2023) Endocrine Reviews , 44(6): 10471073 (Harvard Medical School / University of Pennsylvania) Comprehensive review establishing NAD+ as a cofactor for sirtuins, PARPs, and CD38 enzymes, confirming age-related NAD+ decline as a driver of mitochondrial dysfunction and nuclear-mitochondrial communication breakdown