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Shimizu T, Numata T, Okada Y

While paracellular transmigration involves passage through intercellular junctionsoften exacerbated by disrupted tight junctions under pathological conditionstranscellular transport is facilitated by various endocytic mechanisms, such as clathrin-mediated endocytosis, macropinocytosis, and lipid raft-dependent pathways 157,158,159,160,161

More serious complications, though rare, can include infection at the catheter site if proper sterile technique isn't followed, phlebitis (vein inflammation), and allergic reactions to specific nutrients or preservatives in the solution

In addition, some cancer cell membrane-derived vesicles, such as CCM-FSS and CHM-ABI, have also been confirmed to be important inhibitory strategies