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More serious risks are rare but can include complications such as inflammation of the pancreas or gallbladder problems

CCL-81) and VeroE6/TMPRSS2 (JCRB

In February 2025, the FDA announced that the semaglutide shortage was over, meaning compounding pharmacies can no longer make identical versions of FDA-approved Wegovy

Another study showed that after 26 weeks of treatment with a different GLP-1 receptor agonist (liraglutide), people had improvements in their mental health and energy levels, compared to people who received a placebo.