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The anti-apoptotic effects of GLP-1 have been found in animal models and in cultured pancreatic beta cell lines 6,7

Zhao M, Chen Y, Ding G, Xu Y, Bai M, Zhang Y, Jia Z, Huang S, Zhang A (2016) Renal tubular epithelium-targeted peroxisome proliferator-activated receptor- maintains the epithelial phenotype and antagonizes renal fibrogenesis

Orforglipron also reduced non-HDL cholesterol, triglycerides and systolic blood pressure and decreased high-sensitivity C-reactive protein by 47.7%

GLP-1 receptor agonistsincluding semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)are used to manage type 2 diabetes and obesity in the UK