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Receptor subtype-selective binding and functional assays typically comparing synephrine's potency at beta-1, beta-2, and beta-3 adrenergic receptor subtypes using cAMP accumulation or radioligand displacement methods are used to characterise its relative selectivity profile

[2] [1] For patients with neurological symptoms , hydroxocobalamin 1 mg is given intramuscularly on alternate days until no further improvement occurs, followed by maintenance injections every two months for life

methylcobalamin is a reasonable alternative for this group