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In an effort to encourage the FDA to change its policy, Lee has conducted a series of studies testing BPC-157 on the patients in his clinic and at one other clinic in Florida

Pathway analysis According to the metabolite set enrichment analysis of KOA and control SF samples, tryptophan metabolism, betaine metabolism, glutamate metabolism, cysteine metabolism, glycine and serine metabolism, glutathione metabolism, pantothenate and CoA biosynthesis, taurine and hypotaurine metabolism, methionine metabolism, and homocysteine degradation were the most disturbed pathways (Fig