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Oral Contraceptives Semaglutide's prescribing information includes a dedicated pharmacokinetic substudy evaluating co-administration with a combined oral contraceptive (ethinyl estradiol 0.03 mg / levonorgestrel 0.15 mg)

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Cleveland Clinic and Mayo Clinic both note that these medicines should be started carefully and usually need dose escalation under medical supervision

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142 : 8088 Marcus DL, de Leon MJ, Goldman J, Logan J, Christman DR, Wolf AP et al

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& Chaudhari, N

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