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doi: 10.1016/j.cell.2012.06.024 97 WhittakerSRTheurillatJPVan AllenEWagleNHsiaoJCowleyGSet al

Growing evidence from observational studies indicates that treatment of obesity with bariatric surgery improves cardiovascular outcomes, but these findings have not been confirmed in randomized trials, largely because of randomization challenges with bariatric surgery

Topical peptides function as signaling molecules that communicate with fibroblasts and keratinocytes, stimulating: Collagen synthesis (types I, III, and IV) Elastin production Barrier repair and hydration retention Melanogenesis regulation (relevant to hyperpigmentation research) Key peptide classes studied in dermatology include: Peptide Class Example Primary Function Signal Peptides Palmitoyl Pentapeptide-4 (Matrixyl) Stimulates collagen and elastin production

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