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When combined with levocarnitine, the theoretical benefit is an additive or even synergistic effect on hepatic fat reduction: tirzepatide reduces the caloric load and improves systemic insulin sensitivity, while levocarnitine enhances the liver ability to oxidize existing fat stores and reduce inflammation

In contrast to FTMT, overexpression of ferritin heavy chain 1 (FTH1), which chelates cytosolic iron, moderately inhibited ferroptosis (Supplemental Fig