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The correct method is to start low and titrate the dose up according to the protocol's schedule

In addition to its crucial role in energy metabolism, L-Carnitine is also involved in various other physiological processes, including the removal of metabolic waste products from cells and the regulation of glucose metabolism

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To detect GLP-1R activity in the ex-vivo assay over a sufficient period of time for accurate half-life determination, the dose of the glycosylated variant in the PK stability experiment had to be increased to 40 mg/kg compared to 5 mg/kg for the non-glycosylated fusion