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Excessive generation of reactive oxygen species activates redox-sensitive signalling pathways, including NF-B, leading to sustained release of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1, which impair fibroblast function, collagen synthesis, and neovascularisation

25.2 months for the PIONEER 6 and SUSTAIN-6 trials, respectively) [35,36], the HR of the PIONEER 6 study may have been statistically significant if the follow-up duration had been longer

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The SGID samples were stored at 80C until use