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In the presence of ice nucleating particles (INPs), heterogeneous freezing is catalyzed at warmer temperatures and lower supersaturations 2,3

According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), cough is not listed as an adverse reaction

Weight Loss: In phase III trials, weight loss with the use of exenatide averaged between 0.9 and 2.8 kg over a 30-month time frame, with more weight loss associated when exenatide is added to existing metformin therapy

Furthermore, chronic inflammation is recognized as a key factor in inducing insulin resistance, and GPER can modulate intracellular signaling pathways or suppress the expression of proinflammatory cytokines, which reduces the interference of chronic inflammatory responses and improves insulin resistance [1, 34]