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Gut microbiome imbalance linked to the drug may also affect vaginal health

Hypothalamic tanycytes are glial cells located along the walls and floor of the third ventricle, which are known to play neuroendocrine roles such as detecting and transporting nutrients and hormones like insulin and GLP-1, as well as regulating neuronal activity [60-62]

Some patients find that remaining at a lower maintenance dose, whilst potentially sacrificing some glycaemic or weight loss benefits, provides an acceptable balance between efficacy and tolerability