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5.3 Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin Patients receiving BYETTA in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia including severe hypoglycemia [see Adverse Reactions (6) and Drug Interactions (7)]

1 However, oral administration of protein/peptide therapeutics has proven difficult due to the harsh conditions of the upper gastrointestinal tract and poor absorption rates in the small intestine

However, some people may experience mild digestive upset if they take high doses on an empty stomach

The PNP-1-10-0.05 TZP-4.5 mg/mL hydrogel group demonstrated the largest drop in AUC, reflecting the potent and prolonged glucose-lowering effect of TZP when delivered via hydrogel