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Furthermore, the weight loss effect of GLP-/GIP dual agonists is achieved by combining an increase in energy expenditure with a decrease in food intake [130], and its potential in the treatment of obesity has been validated in clinical trials

Gastrointestinal side effects by dose level The most commonly reported side effects across the full dosing range include constipation , diarrhea , nausea, vomiting, and abdominal discomfort

These include: Hypoglycemia Pancreatitis Gallbladder disease Kidney injury Thyroid malignancy Diabetic retinopathy Allergic reactions Regarding the objective of GLP-1R-A therapy to decrease blood glucose levels, it is possible that these agents could potentially lead to hypoglycemia

Eating becomes intentional instead of compulsive