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None of these pathways directly substitute for another, which is part of why researchers interested in a fuller picture of metabolic regulation may look at all three within the same body of literature not to combine effects, but to understand how separate systems might interact at a mechanistic level

This evidence-based approach avoids unnecessary costs and complexity while ensuring people who truly benefit from b12 addition receive appropriate supplementation

More importantly, taking both supplements may result in excessive intake of other B vitamins, particularly vitamin B6 (pyridoxine) and niacin (B3)

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