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Description

DES(1-3) IGF-1 signals through the same IGF1R PI3K/AKT and MAPK/ERK axes as IGF-1 LR3 but, because it lacks the N-terminal extension that confers extended half-life in LR3, its circulating stability is more comparable to native IGF-1

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Executive function erodes

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Alendronate is excreted renally over 72 hours after a dose, and renal tubular handling of bisphosphonates involves organic anion transport pathways

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Jan 1 2018;187(1):60-74

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