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cAMP, cyclicadenosine monophosphate

Therapeutic considerations include recognizing that weight loss with GLP-1 medications results from both peripheral metabolic effects and central appetite suppression

The challenges: GLP-1s can also: Slow gastric emptying, which increases operative risks Cause slower wound healing if nutritional intake is low Lead to muscle loss, which can reduce recovery strength Continue to suppress appetite during a period where nutrition is critical Some surgeons require: A pause before surgery (often 24 weeks) Evidence of stable nutrition A personalised post-operative plan to avoid nausea and ensure adequate protein intake In short, GLP-1s can help, but they must be used mindfully and usually require a pre- and post-surgery strategy with your healthcare provider

Besides, GLP-1 receptors are also expressed in the human choroid plexus, and the GLP-1-RA exenatide was reported to reduce intracranial pressure in a rodent model as well as in a pilot study on 15 pwIIH [14, 15]