[1] Licensed pharmacological options in the UK include orlistat (available at BMI 30 kg/m, or 28 kg/m with weight-related risk factors) and semaglutide (available within specialist weight management services as per NICE TA875, with adjusted BMI thresholds for some ethnic groups)
In spite of these limitations, the available data provide a strong rationale for further investigation of GLP-1RAs in psoriatic disease
(With insurance and using Novo Nordisks savings card, eligible patients may pay as little as $25 for a 1-month, 2-month, or 3-month supply.) This pricing strategy puts Zepbound in direct competition with compounded alternatives like those offered by Hims & Hers, which recently announced compounded semaglutide for as little as $199/month for customers who agree to a 12-month commitment
[1] Antioxidants in food One possible reason why many studies on antioxidant supplements do not show a health benefit is because antioxidants tend to work best in combination with other nutrients, plant chemicals, and even other antioxidants