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have shown that DENV-2 infection alters oxidative stress by increasing the levels of malondialdehyde (MDA), the end product of lipid peroxidation, and the oxidized glutathione/GSH ratio 126

Thanks to Alex, we have the data right in front of us

careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects

However, whether lipids are oxidized by enzyme action or by ROS attack, the process results in a variety of classic biomarkers of lipid peroxidation such as MDA, 4-HNE, and F2-isoprostane, etc