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The dose escalation schedule of these medications also plays a role, with gastrointestinal symptoms often more pronounced during dose increases

Low intrafollicular oxygenation has been associated with decreased oocyte developmental potential as reflected by increasing frequency of oocyte cytoplasmic defects, impaired cleavage and abnormal chromosomal segregation in oocytes from poorly vascularised follicles [156]

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Promotes the utilization of stored fat for fuel, not just carbohydrates