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Only very small molecules can reliably pass through the skin, which is why patches work for things like nicotine, certain hormones (like estrogen), or some pain medications

Additional significant enrichment categories included coagulation, complement activation, and platelets [98]

Taking the tablet whole also ensures proper absorption thanks to the drug's bioavailability, or the extent to which an active ingredient is absorbed, enters the bloodstream, and reaches the site of action in the body to produce an effect