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The kynurenine pathway, the periphery, and the gut-brain-axis Peripheral KP metabolism is a critical determinant of MDD pathology, acting as a conduit through which systemic inflammation and metabolic stress influence central neurotransmission and neuroplasticity

Medical note: This article is for education only and does not replace medical advice

The selections from each starting point were identical in all dilution factors, replicates and host selection stringencies, with two to four replicate selections per starting point at each stage (Extended Data Fig

Often called the body's master antioxidant, it is one of the few compounds the body makes specifically to manage oxidative stress